Better Being Single? Omics Improves Kidney Organoids

Kidney organoids for disease modeling

Evolving technology: creating kidney organoids from stem cells

The kidney is a complex organ whose excretory and regulatory functions are vital for maintaining homeostasis. Previous techniques used to study the kidney, including various animal models and 2D cell culture systems to investigate the mechanisms of renal development and regeneration have many benefits but also possess inherent shortcomings. Some of those limitations can be addressed using the e...

Generation of kidney tubular organoids from human pluripotent stem cells

Recent advances in stem cell research have resulted in methods to generate kidney organoids from human pluripotent stem cells (hPSCs), which contain cells of multiple lineages including nephron epithelial cells. Methods to purify specific types of cells from differentiated hPSCs, however, have not been established well. For bioengineering, cell transplantation, and disease modeling, it would be...

On being better kidney doctors: understanding trajectories, probabilities, predictability, and people.

I n the last decade, chronic kidney disease (CKD) has become recognized as a more common condition than previously appreciated in the medical field: as a multiplier of risk and as an important prognostic factor for a number of health outcomes, such as cardio-vascular disease, hospitalization, dialysis, and death. 1,2 Universally, it now is recognized as a public health problem, requiring attent...

“Omics” Tools for Better Understanding the Plant–Endophyte Interactions

Endophytes, which mostly include bacteria, fungi and actinomycetes, are the endosymbionts that reside asymptomatically in plants for at least a part of their life cycle. They have emerged as a valuable source of novel metabolites, industrially important enzymes and as stress relievers of host plant, but still many aspects of endophytic biology are unknown. Functions of individual endophytes are...